Why is this significant?

Traditional liquid biopsy test have a high false-positive rate that often leads to additional expensive diagnostic test. This approach taps into the intercellular communication system of the body and uses an AI intelligent enabled protein market to accurately predict malignancy. It also flagged 74% of stage 1 ovarian and 73% of pathologic stage 1A lethally aggressive ovarian adenocarcinomas (5 X more accurate than the current liquid biopsy test)[1].

What is High-Conductance Dielectrophoresis?

Tumors shed nanoparticles containing cancer biomarkers into circulation. The two types are extracellular vesicles, such as exosomes, that contain protein biomarkers and cell-free DNA (cfDNA) containing cancer related mutations. These particles are a challenge to use in cancer screening because they are difficult to recover from plasma using traditional methods. Alternatively, a DEP chip technology can simultaneously collect both types of particles quickly from undiluted plasma and wash it to purify the desired nanoparticles. This enables quantifiable immunostaining of protein biomarkers on the vesicles and fluorescent dye staining of the cfDNA[2].